Refresh AI BiosensorCompany Profile | EverChek CGM | SKD Assembly English Version | 2026.04
01 · Cover
Refresh AI Biosensor

Shenzhen Refresh Biosensing Technology Co., Ltd.

01Company Profile 02Core Product - EverChek CGM 03SKD Component Assembly Solution
2026.04
02 · Contents
Contents

From Core Technology to Scalable Delivery

01

Biosensing Technology

Company Profile

02
EverChek CGM System

EverChek CGM

Core Product

03
SKD 助针器组件横向爆炸图

SKD Component Assembly

Standardized Delivery

Internal Material02
03 · Chapter 01
01
CHAPTER 01

Company Profile

An Innovative Company Integrating Intelligent Biosensing Systems Across the Full Value Chain
Founded in 2016 150+ Patents ISO 13485 National High-Tech Enterprise Specialized & Innovative Enterprise
Internal Material03
04 · Company Overview
01 Company Profile | Company Overview

Company Overview: Integrated Biosensing Innovation Across the Value Chain

Refresh AI BiosensorShenzhen Refresh Biosensing Technology Co., Ltd.
  • Founded in 2016, Shenzhen Refresh Biosensing Technology is built around proprietary biomolecular signal-processing chips. We translate biosensing research into wearable, miniaturized and portable products through an integrated R&D, manufacturing and application platform.
  • With headquarters in Guangming and manufacturing in Longgang, Shenzhen, we operate a 2,000 m² pilot facility for biosensor-based medical devices and wearable electronics. Our capabilities span biosensing, synthesis, microelectrodes, hardware, wearables, reliability and Class 10,000 sterile pilot production.
中国地图及深圳基地位置 Shenzhen Guangming HQ
Operations Center Shenzhen University
Joint Research Center Shenzhen Longgang
Manufacturing Center
光明运营中心企业展示区
龙岗生产制造中心实验室
龙岗生产制造中心洁净走廊
光明运营中心前台

HQ Operations Center

80+ employees; 60%+ in R&D

Intelligent Manufacturing Plant

Supports wireless electronic thermometers (Class II) and CGM (Class III)

Intelligent Biosensing R&D Center

Includes electrode preparation, biosynthesis, crosslinking & membrane-coating, and biosensor fabrication & testing labs

Class 10,000 GMP Pilot Workshop

For Class III medical-device R&D and pilot production, with microelectrode fabrication, digital-droplet chip fabrication, inner/outer membrane preparation & testing, precision molding, and sterility validation

General Assembly Workshop

For Class II and III medical-device assembly/testing and conventional biosensor development & manufacturing, certified to ISO 13485

Internal Material04
05 · Development Journey
01 Company Profile | Development Journey

A Strong Technology Base, Ready to Scale

1 | Concept Validation
Chip and biosensing research foundation
2 | Product Delivery Stage
Applications validated; inflection point reached
3 | Commercial Scale-Up
Mass production and sales
2016
  • Company founded
2017–2019
  • Launched proprietary biochip MS02
  • Academician Zhang Xueji appointed Honorary Chairman and Chief Scientist
  • Selected for the national innovation platform of Tsinghua Institute of Micro/Nanoelectronics and certified as a National High-Tech Enterprise
2020–2021
  • Refresh® wireless electronic thermometer received Class II medical-device certification
  • Refresh®CGM completed its first prototype
  • Launched the BIOSYS biosensing system
  • Received Series A investment from Tsinghua Research Institute Leaguer Venture (Shenzhen government fund)
2022–2024
  • Refresh® wireless electronic thermometer supplied for the Beijing 2022 Winter Olympics
  • CGM design finalized; sterile workshop certified
  • Launched a digital microfluidic electrochemical analysis system
  • Named a Specialized and Innovative Enterprise
  • Secured tens of millions RMB in A+ funding from Shenzhen HTI and Leaguer Venture
2025–2026
  • Refresh® wireless electronic thermometer and sweat-analysis products achieved scaled sales
  • Launched proprietary biochip MS03, with the research-to-market product line fully upgraded and scaled.
  • CGM type testing, clinical evaluation, and registration
  • CGM automated line established for scaled manufacturing
Internal Material05
06 · Scientific Leader
01 Company Profile | R&D Strength | Scientific Leadership

Professor Zhang Xueji Brings Scientific Leadership to the Next Phase of Biosensing Innovation

Zhang Xueji, AIMBE Fellow

With more than 30 years of biosensing research experience, Professor Zhang guides Refresh with scientific rigor, global perspective and cross-disciplinary collaboration.

Academic Appointments

  • Fellow, American Institute for Medical and Biological Engineering
  • Vice President, Shenzhen University
  • National Distinguished Professor
深圳大学 哈尔滨工业大学 解放军总医院 World Precision Instruments ETH Zürich

National Research Roles

  • Chief Scientist, National Major Research Projects
  • Chief Scientist, National Key R&D Programs
  • Advisory Expert, National Major Research Plan
  • Member, Chemistry Advisory Committee of NSFC
  • Deputy Head, Expert Group for Major Synthetic Biology Program, MOST

International Academic Titles

  • Foreign Member, Russian Academy of Engineering
  • Vice Chair, China Center of Russian Academy of Engineering
  • Fellow of the Royal Society (UK)
  • Member of the European Academy of Sciences
Internal Material06
07 · Four Core Technology Capabilities
01 Company Profile | Core Technology

Four Capabilities That Turn Biosensing into Products

From proprietary chips and R&D platforms to sensor modules and adaptive algorithms, our technology is designed to be reused, scaled and transferred.
Biosensing chip evidence: layout, fingertip chip, signal waveform and chip sample
01

Advanced
Biosensing Chips

Proprietary MS02 / MS03 biomolecular signal-processing chips across the signal chain, process, and product lifecycle

Intelligent Biosensing Platform与多形态Sensor Standard Component Biosensor Process Platform与Sensor Standard Component
02

Comprehensive Wearable
Biosensing R&D Platform

Covering electrode preparation, biosynthesis, crosslinking & membrane coating, sensor fabrication, and testing

侵入式BioSensor Standard Component 贴片式BioSensor Standard Component 嵌入式与织物BioSensor Standard Component
03

Multi-Scenario Sensor
Standard Component Capability

Invasive, patch, embedded/textile, miniature temperature, and other component forms

BIOSYS 端云数据与算法分析平台
04

Adaptive
Intelligent Algorithm Platform

Adaptive calibration, compensation, and prediction algorithms for different populations and scenarios

Internal Material07
08 · Technology Platform → Standard Components
01 Company Profile | Market Opportunity | Supply-Side Trends

From Platform Technology to Standardized Biosensing Modules

▸
Underlying Technology
Chips across signal chains, processes, and product lifecycles
Biosensing chip evidence: layout, fingertip chip, signal waveform and chip sample
Electrochemical Biosensing Technology
MS03 Biological Signal-Processing Chip
System Platform
Across R&D, manufacturing, testing, and application
Intelligent Biosensing Platform与多形态Sensor Standard Component
Intelligent Biosensing Platform
  • Biosensor Process Platform
  • Biosensor Testing Platform
  • Biosensor Algorithm Platform
Standardized Sensors
Sample processing, sample testing, miniaturization
微型温度Sensing器Miniature Temperature
Sensor→
贴片式BioSensing器Patch Biosensor→
嵌入式织物BioSensing器Embedded / Textile
Biosensor→
侵入式BioSensing器Invasive Biosensor→
微流控电化学集成chipsMicrofluidic + Electrochemical
Integrated Chip→
Applications
Wearable, personalized, consumer-oriented
RefreshWireless Electronic ThermometerRefresh®Wireless Electronic
Thermometer
RefreshSmart Sweat AnalyzerRefresh®Smart Sweat
Analyzer
Refresh Wearable Smart DiaperRefresh®Wearable
Smart Diaper
Refresh Continuous Glucose Monitoring SystemRefresh®Continuous Glucose
Monitoring System (CGM)
电化学Molecular POCT AnalyzerElectrochemical Molecular
POCT Analyzer
Internal Material08
09 · Intellectual Property
01 Company Profile | Intellectual Property

A Growing IP Portfolio Backed by National R&D Programs

150+Total Patents
36Granted Inventions
30Published Inventions
20PCT / International Patents
4Integrated Circuit Certificates
Application Engineering Platform
Patents106
BIOSYS
System⌁
CGM⌁
Molecular POCT✣
◌Sweat Analysis
☁Support Platform
♨Thermometer
◇Solutions
Underlying Technology
Patents19
Process / Materials◇
▦chips
System Platform
Patents25
Biosensing
Platform⌁
♨Electrode Process
Platform
▯Digital Droplet Platform
科技部 2022 年揭榜挂帅重点专项联合申报协议
National Project Support
2022 MOST Key Challenge Program
2022 NSFC Key Project
National Project Support
2022 NSFC Key Project
Internal Material09
10 · Product Portfolio Overview
01 Company Profile | Product Portfolio

One Technology Foundation. Four Product Pathways.

Shared chip and platform technologies shorten the path from concept validation to scalable production.
CORE PRODUCT | FOCUS OF THIS PROPOSAL
EverChek CGM

Refresh®Continuous Glucose Monitoring System (CGM)

14-day wear, no calibration and MARD < 7.8%. A Class III medical device advancing through testing, clinical evaluation and registration, with automated production in preparation.

PRODUCT LINE 1B
Smart Sweat Analyzer

Refresh®Smart Sweat Analyzer

A smart sweat-analysis platform validated with research institutions and elite athletes, now moving into scaled commercialization.

PRODUCT LINE 1C
Wireless Electronic Thermometer

Refresh®Wireless Electronic Thermometer

Class II medical device supplied for the Beijing 2022 Winter Olympics. Coin-sized, with continuous 24-hour temperature monitoring.

PRODUCT LINE 1D
Refresh Smart Urine Monitoring System

Refresh®Urine Monitoring System

A wearable smart diaper designed for quantitative testing of four routine urinalysis indicators.

Internal Material10
11 · Smart Sweat Analyzer
01 Company Profile / PRODUCT LINE 1B

Refresh® Smart Sweat Analyzer: Performance Insight from Every Drop

Smart Sweat Analyzer开盖结构
使用场景
Ecosystem Partnerships
Garmin / Suunto 生态

Precision Sweat Analytics

Microfluidic biosensors capture sweat data in real time, turning an overlooked signal into practical performance insight.

Understand Exertion. Plan Recovery.

  • Track biochemical signals throughout a workout, with threshold alerts that support safer training.
  • Turn live data into personalized replenishment guidance.

Built for Real-World Use

  • Validated with research institutions and professional athletes.
  • Designed for sports, wellness and data-driven performance programs.
Internal Material11
12 · Sweat Analysis | Four Capabilities
01 Company Profile / PRODUCT LINE 1B

Four Sweat Signals. Clearer Training Decisions.

Works with Garmin / Suunto ecosystems to turn continuous signals into timely wearable alerts.
01

Replenishment Plan

Combines sweat-loss patterns and exercise duration to recommend hydration and electrolyte replenishment.

Build Endurance
02

Cramp Warning

Tracks potassium-loss patterns to identify fatigue signals and support earlier cramp-risk intervention.

Train More Safely
03

Hydration Status

Estimates hydration status continuously and adapts replenishment prompts as conditions change.

Avoid the “Wall”
04

Lactate Threshold

Combines heart-rate and activity data to estimate intensity, lactate threshold and energy expenditure.

Live Molecular Feedback
APP 与穿戴端Real-Time反馈
展会现场产品演示
现场产品交流演示
Internal Material12
13 · Wireless Electronic Thermometer
01 Company Profile / PRODUCT LINE 1C

Refresh® Wireless Electronic Thermometer: Continuous Precision, Simplified

Wireless Electronic Thermometer
Refresh®Wireless Electronic Thermometer Mercury Thermometer Ear / Forehead Thermometer
Continuous Monitoring24-hour monitoringNoneNone
Ease of UseCoin-sized; worn under the arm for comfortable, easy measurementPoor; fragileDifficult for small infant ear canals
Measurement Speed1 minute5 minutes3 seconds
Measurement PrincipleBiosensing temperature measurementMercury thermal expansionInfrared remote sensing
Smart FeaturesRemote app sharing with high-temperature alertsNoneDisplay only
Price RMB 199 for retail RMB 5–15RMB 100–500
Internal Material13
14 · Thermometer | Application Scenarios
01 Company Profile / PRODUCT LINE 1C

Continuous Temperature Insight for the Moments That Matter

Infants & Children连续测温
Infants & Children
Continuous temperature monitoring with 24-hour records for caregivers
Solve Core Pain Points; Rapidly Replace Existing Products
  • 24-hour continuous monitoring and high-temperature alerts reduce caregiver burden; a kick-off-cover function helps avoid repeated night checks
  • Recurring influenza and other infections drive demand; fully traceable data supports discussions with clinicians
备孕期女性基础体温监测
Adults
Continuous temperature monitoring for women preparing for pregnancy
Continuous Basal Temperature Monitoring, Easy to Use
  • Continuous basal-temperature tracking helps women planning pregnancy understand ovulation cycles
  • Connects online consultations and medical information for timely access to professional advice
Basal temperature is meaningful only when collected continuously and consistently; the adhesive-wear format naturally fits this routine.
养老机构体温监测
Older Adults
Care-home temperature monitoring / independent use by older adults
Real-Time Monitoring, Large-Screen Display
  • Older adults can view temperature easily on an independent large display without a phone
Care facilities can review residents’ temperatures centrally, receive automatic abnormal alerts, and reduce manual rounds.
Internal Material14
15 · Urine Monitoring System
01 Company Profile / PRODUCT LINE 1D

Refresh® Urine Monitoring System: A Smarter Foundation for Infant Care

Quantitative, Dynamic Urine Analysis

  • Detect urination frequency, volume, and stool events
  • Use electrochemistry for quantitative testing of urine pH, ascorbic acid, total protein, and glucose
  • Provide results and behavioral guidance linked to user physiological indicators

Adaptable to Multiple Sensors

  • Configurable biosensors enable multi-channel, multi-analyte detection
  • Fully automated monitoring, analysis, upload, and visualization

Multiple Potential Use Cases

  • Smart Diaper
  • Public-restroom urine-sample analysis in designated locations
  • Treatment monitoring in rehabilitation centers
RefreshSmart Diaper示意图
Based on Its Underlying Technology Platform
The Company Enables Fast, Efficient R&D Collaboration with New-Industry Partners
2024.12
Complete joint R&D and testing
2025.6
Align on commercial mass production
2025–2026
Begin product supply and scale sales
★ Initial purchase intent for urine sensors reaches hundreds of millions of units
Open a new era of collaborative R&D, expand into more products through the core sensing platform, and build a second growth curve
Internal Material15
16 · Chapter 02
02
CHAPTER 02

Core Product
Refresh EverChek CGM

Designed for confidence every day: accurate, effortless continuous glucose monitoring.
14-Day Wear No Calibration MARD < 7.8% IPX8 3g
Internal Material16
17 · Product Specifications
02 Core Product / Product Specifications

EverChek CGM at a Glance

MARD | Mean Absolute Relative Difference
< 7.8%
Designed to outperform mainstream CGM accuracy benchmarks
Wear Duration
14 days
Data Transmission
5 min
Calibration Mode
No Calibration
Warm-Up Time
1 hr
Water Resistance
IPX8
Weight
3g
Product Format
Disposable
Alerts
Real-Time Alerts
Refresh EverChek 整机与 APP
Internal Material17
18 · Easier Management
02 Core Product / 01 User Experience

Diabetes Management, Without the Extra Steps

No Fingersticks. No Scanning.

Every 5 minutes, EverChek sends current glucose data directly to your phone. Enhanced Bluetooth connectivity also keeps your smartwatch in sync—no fingersticks, scanning or calibration required.

5 min
Automatic Transmission Interval
—
No Scanning / No Calibration
4
Android / HarmonyOS / iOS + Smartwatch Sync
Daily Use
App Real-Time Glucose Screen
Internal Material18
19 · Integrated Design
02 Core Product / 02 Wear Experience

All-in-One Design. Two Simple Steps.

Compact by design. Comfortable in daily life.
Wear Appearance

A coin-sized, all-in-one applicator makes placement quick and intuitive. Apply in two steps and start monitoring with confidence.

Two Steps to Start Monitoring
Step 1
1
Twist Off the Applicator Cap
Step 2
2
Place on the Upper Arm and Press to Apply
Internal Material19
20 · Waterproof Design
02 Core Product / 03 Daily Scenarios

Waterproof for Everyday Life

Shower | Sweat | Swim | Sleep
Swimming with EverChek CGM
Sleep
IPX8
Top-tier continuous-immersion protection, exceeding mainstream IPX7 solutions
All-Day, All-Weather Wear
  • Shower / Bath
  • High-Intensity Sweating
  • Swimming & Water Sports
  • Wear Overnight
Internal Material20
21 · Personalized Glucose Reminders
02 Core Product / 04 Reminder Features

Alerts That Fit Your Routine

Set the glucose range that works for you and receive timely high / low alerts.
Glucose Alert Screen

Instant High / Low Glucose Reminders

When glucose leaves your chosen range, your phone and smartwatch send synchronized alerts for prompt action

Custom Target Range

Set your target range freely based on clinical advice and personal needs (e.g., 3.0-10 mmol/L)

Real-Time
Reminder Response
5 min
Data Refresh
Phone + Watch
Dual-Device Alerts
Internal Material21
22 · Understand Daily Glucose Patterns
02 Core Product / 05 Data & Reports

Turn Daily Glucose Data into Clearer Decisions

See the relationship between food, exercise and medication in one clear view.

Live Glucose Trends

Switch between 3-, 6-, 12- and 24-hour views to spot fluctuations quickly.

TIR Time in Range

Quantify management results through segmented time-in-range statistics

AGP Ambulatory Glucose Profile

Overlay multi-day data to identify recurring high and low glucose periods

Event Log

Log diet, exercise, medication, and insulin events for linked analysis with glucose curves

Give Every Decision Data Support
Share reports directly with clinicians to guide dietary, exercise, and medication adjustments
TIR / AGP Report Screen
Internal Material22
23 · Competitive Comparison
02 Core Product / Appendix | Competitive Comparison

8 of 9 Core Metrics Match or Exceed Best-in-Class Competitors

Benchmarked against leading Dexcom, Abbott and Medtronic models. Refresh EverChek is highlighted.
Key Metric
THIS PRODUCT
Refresh EverChek 持续葡萄糖监测System
Refresh EverChek
Dexcom G7
Dexcom G6
Abbott
Freestyle 2
Medtronic
Medpac
Calibration
No Calibration
No Calibration
No Calibration
No Calibration
2× Daily
MARD Accuracy
< 7.8%Leading
8.2%
9%
9.30%
12%
Drug Interference Resistance
Yes
Yes
Yes
No
No
Monitoring Frequency
5 minutes
5 minutes
5 minutes
15 minutes
5 minutes
Sensor Wear Duration
14 days
10.5 days
10 days
14 days
7 days
Water Resistance
IPX8
IPX8
IPX7
IPX7
IPX7
Alert Function
Real-Time Alerts
Real-Time Alerts
Real-Time Alerts
Real-Time Alerts
Abnormal Alerts Only
Warm-Up Time
1 hr
30 min
1 hr
1 hr
2 hr
Transmitter Format
Disposable
Disposable
100 days
Disposable
About 1 Year (Rechargeable)
Internal Material23
24 · Chapter 03
03
助针器爆炸图
Applicator Exploded View
CHAPTER 03

SKD Component Assembly Solution

Party B provides the core sensor, key structural components, process standards and registration documents; Party A is responsible for local assembly, traceability and on-site quality control.
Bill of Materials Assembly Process Quality Control & Traceability
Internal Material24
25 · SKD Collaboration Model
03 SKD Solution / Collaboration Model

SKD Collaboration Model & Responsibilities

For EverChek CGM SKD assembly delivery and registration technical collaboration support

Party B Provides

  • Core Sensor
  • Key Structural Components
  • Process Parameters & Quality-Control Standards
  • Technical Documents for Registration

Party A Responsibilities

  • Local Assembly Execution
  • Production Records & Batch Traceability
  • On-Site Quality Control
Assembly Process (10 Steps)
01
Applicator Inner Assembly
02
Applicator Assembly
03
PCBA Assembly
04
Transmitter Assembly
05
Adhesive Application
06
Final Product Assembly
07
Bottom-Cap Closure
08
Inspection
09
Inner Packaging
10
Outer Packaging
Quality Control & Traceability
Critical-Component Batch Records
Battery & Magnet Polarity Check
Seal Integrity Test
Functional Test Record Retention
Conformity with ISO 13485 and Local Regulations
Internal Material25
26 · Selected Bill of Materials
03 SKD Solution / Delivered Materials

Selected Bill of Materials

Three applicator structural components 1 / 1A / 1B, plus transmitter assembly 2
Applicator Upper Shell & Inner Component
1

Applicator Upper Shell

White outer shell shown

Outermost white applicator shell for gripping and actuation

1A

Applicator Inner Component

Blue inner core shown

Blue inner core carrying the transmitter and firing mechanism

Applicator Bottom Shell
1B

Applicator Bottom Shell

Bottom shell of the applicator

First assembled with the internal ring structure to form the bottom-shell assembly

Transmitter Assembly
2

Transmitter Assembly

Core electronic assembly, supplied complete by Party B

Sensor Standard Component Guide Needle PCBA
Internal Material26
27 · Assembly Steps 1–2
03 SKD Solution / Assembly Process (1/2)

Simplified Assembly Steps

1
Applicator Inner Assembly
STEP 01

Install Transmitter Assembly (2) into Applicator Inner Component (1A). Confirm the sensor and guide needle are in place, then put the assembly into the fixture.

1A Applicator Inner Component
+
2 Transmitter Assembly
→
Inner assembly complete; place in fixture
2
Applicator Assembly
STEP 02

Install the internal ring structure into the Applicator Bottom Shell (1B) using the locating tabs to form the bottom-shell assembly.

Internal Ring Structure (observe locating tabs)
+
1B Applicator Bottom Shell
→
Bottom-Shell Assembly
Internal Material27
28 · Assembly Steps 3–4
03 SKD Solution / Assembly Process (2/2)

Simplified Assembly Steps

3
Final Product Assembly
STEP 06

Assemble the Inner-Core Component with the Bottom-Shell Assembly, then fit it into Applicator Upper Shell (1) to complete the applicator body.

Inner-Core Component
+
Bottom-Shell Assembly
→
Applicator Body
4
Bottom-Cap Closure
STEP 07

Use an electric screwdriver at the specified torque to fasten the Bottom Screws. After bottom-cap closure, proceed to inspection and packaging.

Applicator Body
+
Bottom Screws
→
电动螺丝刀锁付助针器Bottom Screws
Torque-Controlled Electric Screwdriver Fastening
Internal Material28
29 · Closing
Refresh AI Biosensor

Thank You

Refresh AI Biosensor | More Than Refresh
2026.04